| Abstrakt: |
1. Using electrophysiological techniques, the endoanesthetic effect of benzononatin (Tessalon, Ciba AG) on peripheral receptive endings was studied in dogs and cats, slightly anesthetized with chloralose or nembutal. 2. Because of its localanesthetic properties, Tessalon (1 - 5 mg/kg i.v.) paralyses lung stretch receptors, baroceptors of the aortic arch, left and right atrial receptors, primary and secondary muscle spindle endings and chemoreceptors. 3. Differences in strength and duration of the 'endoanesthetic' effect depend on several factors: slowly adapting receptors show a more pronounced desensitation for a longer time than do quickly adapting receptors, a fact, which agrees with results on generator potentials. The contact concentration of the endoanesthetic agent on the receptor is influenced by dosage/time, site of application and anatomical localisation of the receptor related to the blood vessels. [ABSTRACT FROM AUTHOR] |
