| Autor: |
Danhauser, Susanne, Berdel, Wolfgang, Schick, Hans, Fromm, Michael, Reichert, Anneliese, Fink, Ulrich, Busch, Raymonde, Eibl, Hansjörg, rastetter, Johann |
| Zdroj: |
Lipids; Nov1987, Vol. 22 Issue 11, p911-915, 5p |
| Abstrakt: |
Eleven lipids have been tested for cytotoxic (trypan blue dye exclusion) activity in cells from eight freshly explanted human leukemias in vitro. 4-Aminomethyl-1-[2,3-(di-N-decyloxy) N-propyl]-4-phenylpiperidine (CP-46,665), 1-mercapto-hexadecyl-2-methoxymethyl- rac-glycero-3-phosphocholine (BM 41.440), the 2-acetamide analog of platelet-activating factor (PAF) and 1- O-octadecyl-2- O-methyl- rac-glycero-3-phosphocholine (ET-18-OCH) were found among the most active compounds. 2-Lysophosphatidylcholine (2-LPC) showed the lowest activity. However, in addition there was variation among the results regarding the activity of the 1-octadecyl- rac-glycero-3-phosphocholine (ET-18-OH) and its D- and L-forms, but a significantly higher cytotoxic activity of D-ET-18-OH compared with L-ET-18-OH on the basis of 2-LPC as control after an incubation time of 48 hr. We conclude that with the limited number of structures available, this type of study is not sufficient to yield further information about the mode of the accumulation and toxicity of this type of lipids. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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