Systematic Investigation of the Kinetic Resolution of 3-Hydroxy Fatty Acid Esters Using Candida antarctica Lipase B (CALB) and the Influence of Competing Oligomerization on the Enantiomeric Ratios.

Autor:	Braner, Markus, Zielonka, Stefan, Auras, Sylvia, Hüttenhain, StefanH.
Předmět:	CHEMICAL kinetics FATTY acid esters CANDIDA LIPASES OLIGOMERIZATION ENANTIOMERS SUBSTRATES (Materials science) ACYLATION
Zdroj:	Synthetic Communications; Apr2012, Vol. 42 Issue 7, p1019-1025, 7p, 3 Graphs
Abstrakt:	The kinetic resolution of 3-hydroxy fatty acid esters C8:0 to C16:0 with Candida antarctica lipase B shows common plots of the enantiomeric excesses of the product and substrate, respectively, versus the conversion and an enantiomeric ratio E of 27 calculated from ee(p). Differences in E, either calculated from the products or the substrates, could be explained by competing oligomerization as a second substrate-consuming process. This reaction is slow compared to acylation, and the remaining enantiomer was oligomerized. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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