| Autor: |
Oosting, E., Richardson, F., Keyzer, J., Wolthers, B., Agoston, S., Langrehr, D. |
| Zdroj: |
Agents & Actions; Jun1987, Vol. 21 Issue 1/2, p54-61, 8p |
| Abstrakt: |
We investigated histamine release in five female patients, submitted for gynaecological surgery, after intravenous administration of the neuromuscular blocking agent d-tubocurarine. In these patients we measured the plasma levels of histamine and its metabolites, N-methylhistamine and N-methylimidazoleacetic acid, making use of mass fragmentographic methods. The newly developed determination of plasma N-methylimidazoleacetic acid had a within-day coefficient of variation of 2.7% ( n=10). Normal values of N-methylimidazoleacetic acid in plasma ranged from 41.3-75.6 nmol/l ( n=13). All five patients developed anaphylactoid reactions: two patients showed severe systemic reactions, one patient a minor systemic reaction and two had skin reactions only. Plasma histamine and N-methylhistamine levels appeared to be the most reliable biochemical parameters for confirming both the occurrence and severity of an anaphylactoid reaction. In comparison with plasma histamine, the determination of plasma N-methylhistamine is less hampered by artefacts caused by blood collection and plasma preparation. Together with the fact that the increase in plasma N-methylhistamine levels after anaphylactoid reactions lasts much longer than the increase in plasma histamine levels, this leads to the conclusion that the determination of plasma N-methylhistamine is a useful retrospective parameter for histamine release in this type of pathological state. The plasma N-methylimidazoleacetic acid levels fluctuated considerably, showing only a significant increase after administration of d-tubocurarine in the two patients who had severe anaphylactoid reactions. This parameter is, therefore, less useful in such studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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