| Autor: |
Yamazaki, Gunji, Nakagawara, Gizo, Okamoto, Hiroshi, Akimoto, Ryuichi, Kimura, Shoichi, Kojima, Yasuhiko, Miyazaki, Itsuo |
| Zdroj: |
Japanese Journal of Surgery; Jun1978, Vol. 8 Issue 2, p152-158, 7p |
| Abstrakt: |
Langerhans islets were isolated from the exocrine pancreata of Wistar rats by the improved collagenase-digestion method. The isolated islets were preserved in a tissue culture medium for seven days. Transplantation of these preserved islets into the portal vein of streptozotocin-induced diabetic rats resulted in a significant reduction of hyperglycemia, polyuria and glucosuria, and a restoration of weight gain. It was found that these effects could be maintained for 16 weeks. In order to normalize the K-values and plasma insulin levels, at least 600 islets had to be transplanted into each diabetic rat. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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