| Abstrakt: |
After two months feeding either an (n-3) or an (n-6) fatty acid-rich diet, two groups of trout were switched to the (n-6) or the (n-3) fatty acid-rich diet, respectively. Half of each group was treated with 0.03% 5,8,11,14-eicosatetraynoic acid (ETYA) in the diet. Liver and intestinal brush border membrane lipids were analyzed. No effect was observed on their cholesterol content. ETYA induced an accumulation of 18∶2(n-6), and it did not affect the 20∶4(n-6) content but decreased the 22∶5(n-6) content. ETYA induced an increase of 18∶3(n-3) content in the brush border membrane and a decrease of the 22∶6(n-3) content in the liver. Those results suggest that ETYA blocks mainly the Δ6-desaturase, which should have two different sites in the liver and one in the intestine. [ABSTRACT FROM AUTHOR] |
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