| Autor: |
Mastrocola, T., Lambert, I., Kramhøft, B., Rugolo, M., Hoffmann, E., Lambert, I H, Kramhøft, B, Hoffmann, E K |
| Zdroj: |
Journal of Membrane Biology; 1993, Vol. 136 Issue 1, p55-62, 8p |
| Abstrakt: |
Trypsinized human skin fibroblasts in suspension perform regulatory volume decrease (RVD) after cell swelling in hypotonic medium. During RVD, 36Cl- efflux is dramatically increased and the cell membrane is depolarized, indicating the activation of Cl- channels. This activation of Cl- channels depends on extracellular as well as on intracellular Ca2+. The swelling-induced Cl- efflux and the RVD response are inhibited by the 5-lipoxygenase inhibitor ETH 615-139. Finally, following hypotonic treatment, cellular pH decreases. The pH decrease does not involve the Cl-/HCO3- exchange because it is independent of the external Cl- concentration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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