| Autor: |
Sullo, Pasquale, Cuocolo, Alberto, Nicolai, Emanuele, Cardei, Stefania, Nappi, Antonio, Squame, Fiorenzo, Covelli, Eugenio, Pace, Leonardo, Salvatore, Marco |
| Zdroj: |
European Journal of Nuclear Medicine; Jun1996, Vol. 23 Issue 6, p648-655, 8p |
| Abstrakt: |
The aim of this study was to evaluate the accuracy of quantitative 1-day exercise-rest technetium-99m tetrofosmin tomography in the identification of patients with coronary artery disease (CAD) and in the detection of individual stenosed coronary vessels. Sixty-one patients with suspected CAD who underwent coronary angiography and 13 normal volunteers were studied. All patients were submitted to two i.v. injections ofTc-tetrofosmin, one at peak exercise (370 MBq) and the other (1110 MBq) at rest 3 h after exercise (images 15-30 min after injection for both studies). All patients with CAD (≽0% luminal stenosis) ( n=50) had an abnormalTc-tetrofosmin tomogram. Only one patient without significant coronary narrowing showed abnormal findings. Overall sensitivity, specificity and diagnostic accuracy in the detection of individual stenosed vessels were 77%, 93% and 85%, respectively. Sensitivity and diagnostic accuracy in the identification of individuals stenosed coronary vessels were significantly higher ( P<0.05) in patients with single-vessel disease ( n=21) than in those with multivessel disease ( n=29). Sensitivity, specificity and accuracy for detecting individual diseased vessels were similar in patients without previous myocardial infarction ( n=26) and in those with previous myocardial infarction ( n=35). In myocardial territories related to non-infarcted areas ( n=128), sensitivity and specificity in the detection of stenosed vessels were 70% and 95%, respectively. In infarcted areas ( n=55), sensitivity and specificity in the detection of stenosed vessels were 85% ( P=NS vs non-infarcted areas) and 75% ( P<0.05 vs non-infarcted areas), respectively. Finally, sensitivity was significantly lower ( P<0.05) in vascular territories supplied by vessels with moderate stenosis (50%-75%) than in those supplied by vessels with severe stenosis (>75%). The results of this study demonstrate that quantitative 1-day exercise-restTc-tetrofosmin single-photon emission tomographic imaging is a suitable and accurate technique to identify patients with CAD and to detect individual stenosed coronary vessels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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