| Autor: |
Bloemink, Marieke J., Heetebrij, Robert J., Ireland, Joanne, Deacon, Glen B., Reedijk, J. |
| Zdroj: |
Journal of Biological Inorganic Chemistry (JBIC); Aug1996, Vol. 1 Issue 4, p278-283, 6p |
| Abstrakt: |
The interaction of the new antitumor-active platinum organoamide complexes [Pt{N( p-HCF)CH}(py)] and [Pt{N(CF)CH}(py)] (py = pyridine) with small G-containing (oligo)nucleotides [GMP, d(GpG)] has been studied to establish whether or not these compounds can bind to DNA in an analogous manner to cisplatin. The reaction products have been analyzed by H, F and P NMR spectroscopy. From the NMR data it is concluded that the {Pt(py)} moiety binds to the N7 position of the G base, analogously to cisplatin, with the organoamide ligand acting as the leaving group. For the GG- N7, N7 adduct, structural differences are found for the sugar conformation, compared with cisplatin. These differences may account for the activity of these new compounds in tumor cell lines resistant to cisplatin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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