Hepatic intra-arterial infusion of vincristine.

Autor:	Jackson, Don, Richards, Frederick, Spurr, Charles, Long, Tony, Rardin, Duff, Albertson, David, Sterchi, J., Jackson, D V Jr, Richards, F 2nd, Spurr, C L, Long, T R, Rardin, D A, Albertson, D A, Sterchi, J M
Předmět:	COMPARATIVE studies HEPATIC artery LIVER tumors RESEARCH methodology MEDICAL cooperation RESEARCH RESEARCH funding VINCRISTINE EVALUATION research INTRA-arterial infusions
Zdroj:	Cancer Chemotherapy & Pharmacology; Aug1984, Vol. 13 Issue 2, p120-122, 3p
Abstrakt:	Currently the chemotherapeutic agents available for intra-arterial infusion in metastatic liver cancer are limited to only a few. The recent demonstration of the feasibility of prolonged IV infusion of vincristine led to exploration of hepatic intra-arterial infusion of this agent. A continuous infusion of 0.4 mg total dose was administered daily for 5 days via a hepatic artery catheter to each of six patients with metastatic liver cancer. Transient but life-threatening toxicity principally involving the nervous and gastrointestinal systems occurred in five of them. Future investigation of hepatic intra-arterial infusion of vincristine should be based on dose-schedules other than that employed in the current trial. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink