Distribution, metabolism, and irreversible binding of hexamethylmelamine in mice bearing ovarian carcinoma.

Autor:	Garattini, Enrico, Colombo, Tina, Grazia Donelli, Maria, Catalani, Paolo, Bianchi, Marina, D'Incalci, Maurizio, Pantarotto, Claudio, Garattini, E, Colombo, T, Donelli, M G, Catalani, P, Bianchi, M, D'Incalci, M, Pantarotto, C
Předmět:	ANIMAL experimentation ANTINEOPLASTIC agents COMPARATIVE studies HETEROCYCLIC compounds RESEARCH methodology MEDICAL cooperation MICE OVARIAN tumors RESEARCH RESEARCH funding EVALUATION research
Zdroj:	Cancer Chemotherapy & Pharmacology; Aug1983, Vol. 11 Issue 1, p51-55, 5p
Abstrakt:	The covalent binding of hexamethylmelamine (HMM) and its metabolites was studied in liver, tumor, blood, kidney, spleen, lung, brain, heart, and small intestine after a single IP injection of 2,4,6-14C-hexamethylmelamine (50 mg/kg) to C57Bl/6J female mice bearing 20-day-old M5076/73A ovarian cancer. Covalent binding to tissue macromolecules was measured 2, 10, and 40 h after injection of the drug. At 2 h liver and small intestine showed the highest levels of irreversibly bound metabolites, the lowest being found in brain and heart. Except in the small intestine, where a decrease was observed between 2 and 10 h, the level of covalent binding was constant up to 40 h. HMM metabolism was also studied. Tissue distribution of pentamethylmelamine (PMM), 2,2,4,6-tetramethylmelamine (TMM), and 2,4,6-trimethylmelamine (TriMM) was determined at the three times considered. At 2 h the drug was already extensively metabolized, TriMM being the major metabolite among those determined. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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