| Autor: |
Olson, Leon, Erickson, Barbara, Hinsdill, Ronald, Wyman, Jeffrey, Porter, Warren, Binning, Larry, Bidgood, Richard, Nordheim, Erik |
| Zdroj: |
Archives of Environmental Contamination & Toxicology; Jul1987, Vol. 16 Issue 4, p433-439, 7p |
| Abstrakt: |
The effects of aldicarb (a carbamate insecticide and nematocide) on selected immune and non-immune parameters of mice were examined. The primary objective was to determine whether exposure to low levels of aldicarb through drinking water could affect selected immune functions. Aldicarb was administered via drinking water either at 10, 100, and 1,000 parts per billion (ppb) 2 for 14 days or at 1, 10, 100, and 1,000 ppb for 34 days. The 34-day experiment was repeated twice with minor variations. Aldicarb significantly and repeatedly suppressed the splenic plaque forming cell response to sheep red blood cells at the lowest concentrations tested: the 1 ppb level elicited greater suppression of plaque forming cells and other immune factors than did 1,000 ppb of aldicarb. This inverse dose-response represents a dramatic departure from the classic toxicologic dose-response curve, where toxicity increases with increasing dose levels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink