| Autor: |
Newell, P., Malchow, D., Gross, J. |
| Zdroj: |
Experientia; Dec1995, Vol. 51 Issue 12, p1155-1165, 11p |
| Abstrakt: |
Changes in cytosolic Ca play an important role in a wide array of cell types and the control of its concentration depends upon the interplay of many cellular constituents. Resting cells maintain cytosolic calcium ([Ca]) at a low level in the face of steep gradients of extracellular and sequestered Ca. Many different signals can provoke the opening of calcium channels in the plasma membrane or in intracellular compartments and cause rapid influx of Ca into the cytosol and elevation of [Ca]. After such stimulation Ca ATPases located in the plasma membrane and in the membranes of intracellular stores rapidly return [Ca] to its basal level. Such responses to elevation of [Ca] are a part of an important signal transduction mechanism that uses calcium (often via the binding protein calmodulin) to mediate a variety of cellular actions responsive to outside influences. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
