| Autor: |
Okano, Motohiko, Thiele, Geoffrey M., Davis, Jack R., Nauseef, William M., Mitros, Frank, Purtilo, David T., Okano, M, Thiele, G M, Davis, J R, Nauseef, W M, Mitros, F, Purtilo, D T |
| Předmět: |
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| Zdroj: |
Annals of Internal Medicine; May88, Vol. 108 Issue 5, p693-699, 7p |
| Abstrakt: |
An adenovirus type-2 was isolated from peripheral blood lymphocytes and throat washings from a patient with severe chronic active Epstein-Barr virus infection. Despite the Epstein-Barr virus reactivation, attempts to establish spontaneous lymphoblastoid cell lines from peripheral blood lymphocytes and to immortalize cord lymphocytes with throat washings were unsuccessful due to a marked cytopathic effect. The supernatants from the cultures induced cytopathic effect in cultured cord lymphocytes, MRC-5 cells, A-549 cells, or Vero cells. Virus particles with adenovirus morphology were seen by electron microscopy. Using type-specific antisera, the isolate was identified as adenovirus type-2. In addition, both Epstein-Barr virus and adenovirus type-2 genomes were seen in the colonic tissues and spleen. These results suggest that the combination of Epstein-Barr virus and adenovirus type-2 may be etiologic agents in the development of chronic active Epstein-Barr virus infection in this patient. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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