TNF-α enhances contraction and inhibits endothelial NO-cGMP relaxation in systemic vessels of pregnant rats.

Autor: Giardina, Jena B., Green, Gachavis M., Cockrell, Kathy L., Granger, Joey P., Khalil, Raouf A.
Předmět:
Zdroj: American Journal of Physiology: Regulatory, Integrative & Comparative Physiology; Jul2002, Vol. 52 Issue 1, pR130, 14p, 1 Chart, 28 Graphs
Abstrakt: Presents a study which examined the hypothesis that tumor necrosis factor-α (TNF-α) directly impairs endothelium-dependent relaxation and enhances the contraction in systemic vessels of pregnant rats. Measurement of mean arterial pressure; Effects of endothelium removal on phenylalanine-induced contraction in aortic strips of virgin and pregnant rats; Mechanisms involved in the TNF-α-induced enhancement of vascular contraction.
Databáze: Complementary Index