| Autor: |
Coates, P, Vyakrnam, S, Eady, E.A, Jones, C.E, Cove, J.H, Cunliffe, W.J |
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| Zdroj: |
British Journal of Dermatology; May2002, Vol. 146 Issue 5, p840-848, 9p |
| Abstrakt: |
Summary Background Cutaneous propionibacteria are implicated in acne pathogenesis, although their exact role in the genesis of inflammation is still poorly understood. Agents, including antibiotics, that reduce the numbers of propionibacteria on skin are therapeutic. Resistance in the target organism is a well-recognized consequence of antibiotic therapy for acne but formal prevalence and distribution data are lacking. Objectives To monitor the prevalence of skin colonization by antibiotic-resistant propionibacteria in acne patients attending the dermatology out-patient clinic at Leeds General Infirmary over a 10-year period beginning in 1991, and to examine the distribution of resistant strains on acne-prone skin and in the nares. Methods Propionibacterial samples were obtained from the skin surface of the worst affected site (usually the face) of 4274 acne patients using a moistened swab. The swab was used to inoculate agar plates with and without selective antibiotics. After anaerobic incubation at 37 °C for 7 days, the amount of growth in the presence of each antibiotic was scored on a scale from 0 to 5+. A small number of patients (72) were selected for more detailed quantitative sampling at six different sites to examine the distribution of resistant propionibacteria on acne-prone skin and in the anterior nares. Results The proportion of patients carrying strains resistant to one or more commonly used antiacne antibiotics rose steadily from 34·5% in 1991 to a peak of 64% in 1997. The prevalence dropped to 50·5% during 1999 and then rose again to 55·5% in 2000. Resistance to erythromycin was the most common and the majority of erythromycin-resistant strains were cross-resistant to clindamycin. Resistance to tetracyclines was less common in all years and with little increase over time. The more detailed quantitative study in 72 patients showed that population densities of resistant propionibacteria varied considerably between sites and... [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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