Plasma cholesterol concentration and extra lipid band in monoclonal gammopathies.

Autor: Levy, Y., Aviram, M., Spira, G., Tatarsky, I., Brook, G. J., Carter, A.
Zdroj: Postgraduate Medical Journal; Jul1984, Vol. 60 Issue 705, p449-453, 5p, 1 Black and White Photograph, 3 Charts
Abstrakt: Plasma lipids and lipoproteins were studied in 21 patients with benign monoclonal gammopathy, 21 patients with multiple myeloma and seven patients with Waldenström's macroglobulinaemia. Results were compared with those of a control group, age and sex matched. Low plasma cholesterol levels in all three patient groups were associated with low HDL-cholesterol concentrations. Apo A-I, but not apo B, was significantly reduced. Sixty per cent of the patients exhibited an extra lipid band on plasma lipoprotein electrophoresis, which could be an immunoglobulin-lipid complex. In these patients plasma and LDL-cholesterol levels were significantly lower than in those patients in whom this band was absent. No correlation was found between the severity of the disease and plasma lipid pattern. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index