Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease.

Autor:	Abdo, W. Farid, De Jong, Daniëlle, Hendriks, Jan C.M., Horstink, Martin W.I.M., Kremer, Berry P.H., Bloem, Bastiaan R., Verbeek, Marcel M., De Jong, Daniëlle
Předmět:	PARKINSON'S disease diagnosis BRAIN metabolism BENZAMIDE BRAIN COENZYMES COMPARATIVE studies COMPUTED tomography DIFFERENTIAL diagnosis ELECTROMYOGRAPHY ENZYME-linked immunosorbent assay HETEROCYCLIC compounds LACTIC acid LONGITUDINAL method RESEARCH methodology MEDICAL cooperation NEURODEGENERATION PARKINSON'S disease RESEARCH EVALUATION research SINGLE-photon emission computed tomography ETHYLENE glycols CARBOCYCLIC acids INDOLE compounds IODINE radioisotopes DIAGNOSIS
Zdroj:	Movement Disorders; May2004, Vol. 19 Issue 5, p571-579, 9p
Abstrakt:	We investigated whether cerebrospinal fluid (CSF) analysis discriminates between idiopathic Parkinson's disease (PD; n = 35) and multiple system atrophy (MSA; n = 30). The median CSF concentration of the neurotransmitter metabolites 5-hydroxyindolacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) was reduced significantly (49-70%) in MSA compared to PD. In contrast, several brain-specific proteins (tau, neuron-specific enolase, myelin basic protein) were elevated (130-230%) in MSA compared with those in PD. A combination of CSF tau and MHPG discriminated PD from MSA (adjusted odds ratios: tau, 27.2; MHPG, 0.14). Our data suggest that the more progressive and widespread neurodegenerative nature of MSA, as compared with PD, is reflected in the composition of CSF. We propose that CSF analysis may become part of the diagnostic work-up of patients with parkinsonian syndromes. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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