Potential Role of P-gp for Flavone-Induced Diminished Apoptosis and Increased Adenoma Size in the Small Intestine of APCmin/++ Mice.

Autor:	Schumacher, Marco, Hautzinger, Anja, Rossmann, Annette, Holzhauser, Susanne, Popovic, Daniela, Hertrampf, Anke, Oesterle, Doris, Spiller, Carmen, Boll, Michael, Wenzel, Uwe
Předmět:	ADENOMA FLAVONOIDS SMALL intestine diseases APOPTOSIS CANCER treatment CANCER cells LABORATORY mice GLYCOPROTEINS
Zdroj:	Cancer Investigation; Jul2011, Vol. 29 Issue 6, p396-404, 9p, 1 Color Photograph, 4 Graphs
Abstrakt:	APCmin/++ mice, carrying a nonsense mutation in the adenomatous polyposis coli (APC) gene, appear as a perfect model to study development or therapy of intestinal neoplasia. We tested whether the flavonoid flavone is able to affect adenoma development in APCmin/++ mice. Tumor sizes were significantly increased by flavone selectively in small intestine. This was associated with reduced cell numbers displaying cleaved caspase-3 and enhanced expression of phosphoglycoprotein (P-gp). However, according to great variability in P-gp expression in all parts of mice intestines, an association between expression of P-gp and inhibition of apoptosis was demonstrated in human Caco-2 colorectal cancer cells. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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