| Autor: |
Bondarenko, V. E., Doedel, E. J., Rasmusson, R. L. |
| Předmět: |
|
| Zdroj: |
AIP Conference Proceedings; 2000, Vol. 502 Issue 1, p175, 8p, 17 Graphs |
| Abstrakt: |
We applied bifurcation analysis to the Luo-Rudy model of the guinea pig cardiac ventricular cell to investigate the behavior of repolarization in response to a simulated form of inherited arrhythmia, long QT syndrome. In this paper, we simulate pathological changes in cardiac repolarization through reductions in I[sub Kr]. Decreased expression of this current has been linked to an inherited form of long QT syndrome which results in a high mortality, presumably due to sudden cardiac death from ventricular fibrillation. © 2000 American Institute of Physics. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
