| Autor: |
Díaz, C. Serra, Vizoso, F., Lamelas, M. L., Rodríguez, J. C., González, L. O., Baltasar, A., Medrano, J. |
| Předmět: |
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| Zdroj: |
British Journal of Surgery; Sep99, Vol. 86 Issue 9, p1190-1197, 8p, 3 Black and White Photographs, 3 Charts, 3 Graphs |
| Abstrakt: |
SummaryBackground: Apolipoprotein D (Apo D) is a protein component of the human plasma lipid transport system which is present in benign and malignant human breast tissues. This study analysed the expression of Apo D in men with gynaecomastia or breast cancer, and evaluated its use as a prognostic marker in breast cancer. Methods: Immunohistochemical expression of Apo D was examined in specimens from 15 men with gynaecomastia, two with in situ breast carcinoma and 68 with invasive male breast cancer. Median follow-up in patients with breast cancer was 44 months. Results: All gynaecomastia specimens, both in situ carcinomas and 57 invasive carcinomas (84 per cent) stained positively for Apo D. Apo D values were significantly correlated with axillary node involvement and histological grade of the tumours. In men with breast cancer univariate analysis showed a statistical association between node status and Apo D content with relapse-free survival (P < 0·001) and overall survival (P < 0·05). Cox multivariate analysis showed that Apo D was a significant indicator of relapse-free survival (P = 0·0089), but node status was the strongest factor able to predict both relapse-free (P = 0·0336) and overall (P = 0·0346) survival. Conclusion: Apo D was expressed in gynaecomastia and a high percentage of male breast carcinomas. There was a positive association of Apo D content in male breast tumours with favourable outcome. Apo D expression was a significant independent indicator of relapse-free survival in male breast cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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