| Autor: |
Chan, C. Y., Lai, K. N., Lam, A. W., Li, P. K. T., Chung, W. W. M., French, G. L., Li, P K, Chung, W W |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Feb1991, Vol. 27 Issue 2, p225-232, 8p |
| Abstrakt: |
We investigated the pharmacokinetics of two intravenous (iv) dose regimens of imipenem/cilastatin in Chinese patients on chronic ambulatory peritoneal dialysis (CAPD), who had an average creatinine clearance of 3.2ml/min/l.73m. Doses of 0.5 and 1.0 g produced mean peak serum imipenem concentrations of 30 and70 mg/l respectively, about 60% of cilastatin. Peritoneal dialysis fluid (PDF) imipenem concentrations reached 20–30% of the serum peak 4–5 h after iv injection, and the lowest maximum PDF concentrations were 2 mg/l after the 0.5 g dose and 14 mg/l after 1.0 g. Thus both regimes produced PDF imipenem concentrations above the MICs of susceptible pathogens. The half-life of imipenem was 6.4 h and the plasma clearance 66ml/min; serum and PDF imipenem were in equilibration after about 5 h. Cilastatin had a prolonged half-life of 19 h and a plasma clearance of 10 ml/min, and accumulated in both serum and PDF. With a 0.5 g dose, the pharmacokinetics of imipenem/cilastatin suggest that the combination may prove an effective treatment for peritonitis associated with CAPD. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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