| Autor: |
Matthews, Gail V., Pillay, Deenan, Cane, Patricia, Ratcliffe, Daina, Gazzard, Brian, Nelson, Mark |
| Předmět: |
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| Zdroj: |
Clinical Infectious Diseases; 12/15/2001, Vol. 33 Issue 12, p2049, 6p |
| Abstrakt: |
Individuals coinfected with human immunodeficiency virus 1 (HIV-1) and hepatitis B virus (HBV) often receive treatment with an antiretroviral regimen including lamivudine. Lamivudine monotherapy for HBV may lead to drug-resistant mutations in a significant number of patients. The virological and biochemical responses of 8 patients coinfected with HBV/HIV-1 treated with both lamivudine and famciclovir were studied. Patients exhibiting HBV viral rebound at 1 year were analyzed for the emergence of HBV polymerase mutations. Only 1 patient had no prior exposure to lamivudine. Addition of famciclovir to the treatment regimen resulted in a median fall in HBV DNA level of 0.33 log[sub10] at 3 months and an overall rise in HBV DNA level of 3 log[sub10] at 12 months. The only patient in whom durable viral suppression and HBV e antigen eroconversion were noted began receiving lamivudine and famciclovir simultaneously. HBV polymerase gene sequencing identified resistance-associated mutations in 6 of 7 patients with viral rebound. Sequential nucleoside analogue therapy is unlikely to be successful in achieving long-term suppression of HBV replication, and combination therapy should be considered at treatment initiation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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