| Autor: |
Tauris, P., Peterslund, N. A., Black, F. T., Hansen, P. W., Christiansen, S. E. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Jan1984, Vol. 13 Issue 1, p71-77, 7p |
| Abstrakt: |
The increasing use of the antiviral agent acyclovir has focused the attention to the possible side-effects on cellular and humoral immunological processes. The drug has preclinically been tested extensively but most investigations have been carried-out in animal models. The influence of acyclovir on the proliferation and the plaque-forming capability of pokeweed mitogen (PWM) activated cultures of unfractionated and isolated subpopulations from human peripheral blood lymphocytes (PBL), was investigated. These parameters were monitored with the 3H-thymidine incorporation technique and a protein A plaque-forming cell assay. Acyclovir had little inhibitory effect at physiological concentration whereas a detrimental decrease was noted at higher concentrations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
