| Autor: |
van Houte, L.P.A., RetÈl, J., Westra, J.G., van Grondelle, R. |
| Zdroj: |
Carcinogenesis; 1990, Vol. 11 Issue 4, p701-704, 4p |
| Abstrakt: |
The reactive metabolites of the carcinogenic -acetyl-2-amino-fluorene (AAF) form adducts with the guanine base of DNA. The fluorescence emission characteristics of -(deoxyguansin-8-yl)--acetyl-2-aminofluorene (dGuo-C8-AAF), -(deoxyguanosin-8-yl)-2-aminofluorene (dGuo-C8-AF) and the two N7=C8 imidazole ring-opened products of dGuo-C8-AF (ro-dGuo-C8-AF I + II) were investigated and related to their conformational properties. The dGuo-C8-AF adduct (ø ⋍ 4−5 × 10) shows a broad and structureless emission band, which is attributed to the formation of an excited-state complex. In contrast, the emission spectra of dGuo-C8-AAF (ø ⋍ 1.10) and both ra-dGuo-C8-AF compounds [ø(ro-dGuo-C8-AF I) ⋍ 4.10; ø(ro-dGuo-C8-AF II) ⋍ 4.10 are narrow. This indicates that dGuo-C8-AAF and ro-dGuo-AF I + II do not decay into an exciplex as occurs in dGuo-C8-AF. The spectroscopic features are discussed in terms of the differences in the dynamic structure of the various compounds. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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