| Autor: |
UUSIMAA, P. A., IKÄHEIMO, M. J., RUSKOAHO, H., AIRAKSINEN, K. E. J., HUIKURI, H. V., LINNALUOTO, M. K., TAKKUNEN, J. T., PEUHKURINEN, K. J. |
| Zdroj: |
European Heart Journal; May1993, Vol. 14 Issue 5, p682-686, 5p |
| Abstrakt: |
The inter-relationships between ischaemia-induced metabolic changes and atrial natriuretic peptide (ANP) release were studied in 18 patients undergoing elective percutaneous transluminal coronary angioplasty (PTC A). Transcardiac differences in ANP, lactate, pH, pCO and O saturation were analysed before and after balloon inflation. The patients were divided into ischaemia and non-ischaemia groups on the basis of the change in lactate extraction ratio during balloon inflation. The ischaemia group (patients with a decrease in lactate extraction ratio) showed an increase of 27±15 pg. ml in the transcardiac ANP difference, whereas a decrease of 27±17pg.ml occurred in the non-ischaemia group (no decrease in lactate extraction ratio). The change between the two patient groups was statistically significant (<0.05). Metabolic ‘pre-conditioning’ was not observed in (P<0.05) was obtained between the PTCA-induced changes in transcardiac ANP and lactate differences. We conclude that transient myocardial ischaemia induced by PTCA increases circulating ANP concentrations in patients with signs of metabolic ischaemia, but not in those without. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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