| Autor: |
Xiaofei Zhang, Bertaso, Federica, Jong W. Yoo, Baumgärtel, Karsten, Clancy, Sinead M., Van Lee, Cienfuegos, Cynthia, Wilmot, Carly, Avis, Jacqueline, Hunyh, Truc, Daguia, Catherine, Schmedt, Christian, Noebels, Jeffrey, Jegla, Timothy |
| Předmět: |
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| Zdroj: |
Nature Neuroscience; Sep2010, Vol. 13 Issue 9, p1056-1058, 3p, 3 Graphs |
| Abstrakt: |
We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2−/− (also known as Kcnh3−/−) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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