| Autor: |
Kai Liu, Yi Lu, Lee, Jae K., Samara, Ramsey, Willenberg, Rafer, Sears-Kraxberger, Ilse, Tedeschi, Andrea, Park, Kevin Kyungsuk, Duo Jin, Bin1Cai, Bengang Xu, Connolly, Lauren, Steward, Oswald, Binhai Zheng, Zhigang He |
| Předmět: |
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| Zdroj: |
Nature Neuroscience; Sep2010, Vol. 13 Issue 9, p1075-1081, 7p, 1 Color Photograph, 6 Graphs |
| Abstrakt: |
Despite the essential role of the corticospinal tract (CST) in controlling voluntary movements, successful regeneration of large numbers of injured CST axons beyond a spinal cord lesion has never been achieved. We found that PTEN/mTOR are critical for controlling the regenerative capacity of mouse corticospinal neurons. After development, the regrowth potential of CST axons was lost and this was accompanied by a downregulation of mTOR activity in corticospinal neurons. Axonal injury further diminished neuronal mTOR activity in these neurons. Forced upregulation of mTOR activity in corticospinal neurons by conditional deletion of Pten, a negative regulator of mTOR, enhanced compensatory sprouting of uninjured CST axons and enabled successful regeneration of a cohort of injured CST axons past a spinal cord lesion. Furthermore, these regenerating CST axons possessed the ability to reform synapses in spinal segments distal to the injury. Thus, modulating neuronal intrinsic PTEN/mTOR activity represents a potential therapeutic strategy for promoting axon regeneration and functional repair after adult spinal cord injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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