Involvement of MAPKs and NF-κB in Tumor Necrosis Factor α-Induced Vascular Cell Adhesion Molecule 1 Expression in Human Rheumatoid Arthritis Synovial Fibroblasts.

Autor:	Shue-Fen Luo, Rou-Yi Fang, Hsi-Lung Hsieh, Pei-Ling Chi, Chih-Chung Lin, Li-Der Hsiao, Chi-Chuan Wu, Jong-Shyan Wang, Chuen-Mao Yang
Předmět:	RHEUMATOID arthritis MITOGEN-activated protein kinases NF-kappa B TUMOR necrosis factors CELL adhesion molecules FIBROBLASTS
Zdroj:	Arthritis & Rheumatism; Jan2010, Vol. 62 Issue 1, p105-116, 12p, 5 Diagrams, 6 Graphs
Abstrakt:	The article focuses on a study which examined the roles of mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB in tumor necrosis factor α (TNFα)-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in rheumatoid arthritis synovial fibroblasts (RASF). The study included patients with rheumatoid arthritis (RA) who underwent knee or hip surgery. It concluded that TNFα-induced VCAM-1 expression is mediated by the activation of p42/p44 MAPK, p38 MAPK, JNK, and NF-κB pathways.
Databáze:	Complementary Index
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