Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model....

Autor: Xu Gang Xia, Harding, Thomas, Weller, Michael, Bieneman, Alison, Uney, James B., Schulz, Jorg B.
Předmět:
Zdroj: Proceedings of the National Academy of Sciences of the United States of America; 8/28/2001, Vol. 98 Issue 18, p10433, 6p, 16 Color Photographs, 2 Diagrams, 5 Graphs
Abstrakt: Examines the gene transfer of the c-Jun N-terminal kinase (JNK) interacting protein-1. Protection of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease; Phosphorylation and activation of JNK kinase; Measurement of catecholamine concentrations from MPTP toxicity in mice.
Databáze: Complementary Index