| Autor: |
Grobet, Luc, Poncelet, Dominique, Royo, Luis, Brouwers, Benoit, Pirottin, Dimitri, Michaux, Charles, Ménissier, François, Zanotti, Marta, Dunner, Susana, Georges, Michel |
| Zdroj: |
Mammalian Genome; Mar1998, Vol. 9 Issue 3, p210-213, 4p |
| Abstrakt: |
We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be predicted to disrupt the function of the protein, one is a conservative amino acid substitution, and one a silent DNA sequence variant. Four additional DNA sequence polymorphisms were identified in myostatin intronic sequences. In all but two breeds, all double-muscled animals were either homozygous or compound heterozygotes for one of the five loss-offunction mutations. The absence of obvious loss-of-function mutations in the coding sequence of the two remaining breeds points either towards additional mutations in unexplored segments of the gene, or towards locus heterogeneity of double-muscling. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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