| Autor: |
Shimada, Shinya, Shiomori, Kenji, Honmyo, Ubehiko, Maeno, Masanobu, Yagi, Yasushi, Ogawa, Michio |
| Zdroj: |
Gastric Cancer; Sep2002, Vol. 5 Issue 3, p0130-0136, 7p |
| Abstrakt: |
Background: Our previous studies have demonstrated the significant role of the generative cells of intestinal metaplasia (IM) expressing brain (fetal)-type glycogen phosphorylase (BGP) (BGP-IM) as a premalignant lesion of intestinal-type adenocarcinoma. The aims of the present study were to investigate the incidence of BGP-IM in gastric biopsy specimens and to establish BGP-IM as a predictor of the coexistence of accessory carcinoma and/or metachronous cancers before and after local treatment for early gastric carcinoma. Methods: We studied the incidence of BGP-IM in eight endoscopic biopsy specimens of methylene blue-positive mucosa of the stomach obtained from patients with multiple gastric carcinomas ( n = 14), a single carcinoma ( n = 25), and atrophic gastritis ( n = 20). Results: BGP positivity was 93.3% in the multiple carcinomas and 80.0% in the single carcinomas. The incidences of BGP-IM (mean percentage ± SD) in the stomachs with multiple carcinomas, single carcinoma, and atrophic gastritis were 83.2% ± 22.8%, 36.5% ± 41.3%, and 7.1% ± 18.0%, respectively. The incidence was significantly higher in the stomachs with multiple carcinomas than in those with a single carcinoma or those with atrophic gastritis ( P < 0.001). Conclusion: It is suggested that the frequent appearance of BGP-IM reflects the high potential of carcinogenesis of intestinal-type gastric cancer, and that the involvement of BGP-IM in more than 50% of the eight biopsies may be a predictor of the coexistence of accessory and/or metachronous carcinoma before and after local treatment for early gastric carcinoma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink