| Autor: |
Zmijewski, M. J., Vicenzi, J., Landen, B. E., Muth, W., Marler, P., Anderson, B. |
| Zdroj: |
Applied Microbiology & Biotechnology; Feb1997, Vol. 47 Issue 2, p162-166, 5p |
| Abstrakt: |
In an effort to prepare 3,4-methylene-dioxyphenyl-( S)-isopropanol from 3,4-methylene-dioxyphenylacetone, an initial screen of microbes indicated that Candida famata could catalyze this reaction efficiently at low substrate concentration. A dilute, large-scale process was developed to provide experimental material for the chemical synthesis to be explored. However, the productivity number of this process [0.134 g product (g␣wet␣weight cells)−1 day−1 was too low to be practical. C.␣famata was also extremely sensitive to concentrations of both the ketone and the alcohol greater than 2 g/l. A more extensive screen of yeast and fungi revealed that Zygosaccharomyces rouxii was more tolerant to higher substrate concentrations and had a higher productivity number [0.8 g (g wet weight cells)−1 day−1]. These characteristics suggested that Z. rouxii could be used in a large-scale process at high substrate concentrations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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