| Autor: |
Yılmaz, Ibrahim Arda, Özge, Aynur, Erdal, Mehmet Emin, Edgünl, Tuba Gökdoğan, Çakmak, Sema Erol, Yalın, Osman Özgür |
| Předmět: |
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| Zdroj: |
Pain Medicine; Apr2010, Vol. 11 Issue 4, p492-497, 6p, 2 Charts |
| Abstrakt: |
Objective. There are contrasting results obtained in migraineurs concerning the levels and the role of both pro-inflammatory and anti-inflammatory cytokines. In this study, the association of the occurrence and clinical characteristics of migraine with the polymorphisms of tumor necrosis factor α (TNF-α) −308 G/A (rs1800629), interleukin-1α (IL-1α) +4845 G/T (rs17561), IL-1β+3953 C/T (rs1143634) and interleukin-1 receptor antagonist variable number tandem repeat (IL-1RA VNTR) genes were studied. We also investigated the genetic linkage between these genes. Design, Setting, Patients. Sixty-seven patients with migraine without aura (MwoA) and 96 unrelated, age- and sex-matched migraine-free, healthy control subjects from the same geographic area were investigated. Results. We observed significant differences in the genotypic distribution of the TNF-α−308 G/A and IL-1β+3953 C/T polymorphism for migraineurs compared with controls ( P = 0.004). Frequency of the TNF-α−308 GG genotype was higher in the control group than MwoA group (82.1% vs 55.2%). Differences in the distribution of the allele frequencies were also observed, being the TNF-α−308 G allele overrepresented in control group and TNF-α−308 A allele in MwoA group. In addition, there was a significant increase of the IL-1β+3953 T allele in MwoA cases compared with controls ( P = 0.004). Conclusions. In conclusion, the present results indicate the possible contribution of TNF-α and IL-1β gene polymorphisms to migraine headache generation in MwoA patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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