| Autor: |
Meyer, G., Piepsz, A., Kolinska, J., Lepej, J., Sixt, R., Hahn, K. |
| Předmět: |
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| Zdroj: |
European Journal of Nuclear Medicine; 1998, Vol. 25 Issue 7, p760-760, 6p |
| Abstrakt: |
Abstract. Use of technetium-99m labelled mercaptoacetyltriglycine ([sup 99m]Tc-MAG3) simplifies and improves the quantification of renal clearance in children by virtue of its permanent availability, good imaging properties and low radiation exposure. Due to the lack of reference values for [sup 99m]Tc-MAG3 clearance in children, the Paediatric Task Group of the EANM initiated a multicentre study to evaluate [sup 99m]Tc-MAG3 clearance values in children with minimal renal disease. One hundred and twenty-five children aged between 12 months and 17 years, classified as renally healthy using defined diagnostic criteria, were included in the study. [sup 99m]Tc-MAG3 clearance was calculated using an algorithm on the basis of a single blood sample taken at any time between 30 and 40 min after tracer injection. In addition, the absolute [sup 99m]-Tc-MAG3 clearance values were normalized to body surface area. For further evaluation the children were classified into several groups according to age. There was a continuous increase in non-corrected [sup 99m]Tc-MAG3 clearance values from the age of 1 year up to the age of 17 years (mean value <2 years: 98+/-57 ml/min; mean value >8 years: 208+/-66 ml/min). Normal clearance values for adults were achieved by the age of 8 years. Analysis of the relationship between non-corrected clearance and age yielded a correlation coefficient of r=0.7. When these absolute clearance values were normalized to body surface area, we found nearly constant clearance values for all age groups, with a mean clearance value of 315+/-114 ml/minx1.73 m[sup 2]. The correlation coefficient for... [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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