| Autor: |
Okada, Yoshinori, Kawamoto, Masashi, Fujii, Kohyu, Yuge, Osafumi |
| Předmět: |
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| Zdroj: |
Journal of Anesthesia; 2000, Vol. 14 Issue 3, p124, 4p |
| Abstrakt: |
Abstract Purpose. To determine the pharmacokinetic parameters of propofol after a single-dose injection in Japanese adults. Methods. This study was carried out in adult patients who underwent minor surgery under general anesthesia with sevoflurane. We injected 1.0, 1.5, or 2.0mg.kg[sup -1] of propofol at a constant rate using a syringe pump. Arterial blood samples were taken for 480min after the administration of propofol. The whole-blood concentration of propofol was determined with gas chromatography, and a time-blood concentration curve was analyzed by a two-compartment open-model analysis and a model-independent analysis. Results. The half-lives of the central and peripheral compartment (t[sub 1/2] alpha and t[sub 1/2] beta) were 2.26 +/- 0.69 and 47.9 +/- 22.1 min, respectively. The volume of the central compartment (V[sub c]) was 0.582 +/- 0.1701.kg[sup -1], and the apparent volume of distribution at a steady state (V[sub dss]) was 2.62 +/- 1.061.kg[sup -1]. The total body clearance (C1) and mean residence time (MRT) were 53.7 +/11.9ml.min[sup -1].kg[sup -1] and 98.1 +/- 16.4 min, respectively. Conclusions. Among the pharmacokinetic parameters determined in Japanese adults, t[sub 1/2] alpha, t]sub 1/2] beta, and Vc were similar, V[sub dss] was smaller, and C1 was larger, as compared with values in Caucasians. These findings suggest that propofol could be eliminated well during minor surgery in Japanese adults. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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