Aminoguanidine induces haematuria of non‐glomerular origin in spontaneously hypertensive rats.

Autor: Arai, Takami, Morimoto, Kengo, Oka, Megumi, Hikita, Tomoyuki, Arai, Kentaro, Umezawa, Kiyoshi, Nagase, Mitsumasa, Yamamoto, Tatsuo
Zdroj: Nephrology Dialysis Transplantation; Jun2000, Vol. 15 Issue 6, p811-817, 7p
Abstrakt: Background. Administration of NG‐nitro‐l‐arginine methyl ester (l‐NAME), a non‐selective inhibitor of nitric oxide synthase (NOS), induces glomerulosclerosis in spontaneously hypertensive rats (SHR). We investigated the effects of administering aminoguanidine (AG), a selective inhibitor of inducible NOS (iNOS), on glomerular histology, serum creatinine concentration, albuminuria and haematuria in SHR. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index