| Autor: |
Aloisse, R., de Almeida, A. J., Sion, F. S., Morais-de-Sá, C. A., Gaspar, A. M. C., de Paula, V. S. |
| Předmět: |
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| Zdroj: |
International Journal of STD & AIDS; May2008, Vol. 19 Issue 5, p321-326, 6p, 2 Charts, 1 Graph |
| Abstrakt: |
Shifting of hepatitis A virus (HAV) epidemiology from a high towards an intermediate endemicity pattern and use of antiretroviral therapy increased the risk of HIV/HAV coinfection in developing countries. The aim of this study was to investigate the presence of HAV markers in a cohort of HIV-infected patients from 1988 to 2004. The presence of serum anti-HAV antibodies and HAVRNA by real-time polymerase chain reaction was investigated in 581 patients. Total anti-HAV antibodies was found in 464/581 (79.8%) patients, however, achanging epidemiologic pattern of hepatitisAamongHIV-infected patients from1988 to 2004was observed.Among patients susceptible to HAV (n ¼ 117), 5 (4.2%) were coinfected with HAV, all of them had IgM anti-HAV antibodies and were serum HAVRNA- positive. The high prevalence of anti-HAV antibodies in HIV-infected patients suggests that screening tests for anti-HAV antibodies should be performed before implementation of hepatitis A vaccination, especially in those patients from endemic countries. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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