Mineralization and Bone Resorption Are Regulated by the Androgen Receptor in Male Mice.

Autor: Cherie Chiang, Chiu, Maria, Moore, Alison J., Anderson, Paul H., Ghasem-Zadeh, Ali, McManus, Julie F., Ma, Cathy, Seeman, Ego, Clemens, Thomas L., Morris, Howard A., Zajac, Jeffrey D., Davey, Rachel A.
Zdroj: Journal of Bone & Mineral Research; Apr2009, Vol. 24 Issue 4, p621-631, 11p
Abstrakt: The article discusses research which found that androgen receptors (AR) regulate mineralization and bone resorption in male knockout mice. Researchers inactivated the AR in differentiated osteoblasts that were mineralizing and observed a decreased volume of femoral trabecular bone which indicated increased bone resorption.
Databáze: Complementary Index