| Autor: |
KOUSVELARI, E. E., FOX, P. C., BAUM, B. J. |
| Předmět: |
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| Zdroj: |
Journal of Dental Research; Feb1987, Vol. 66 Issue 2, p552-556, 5p, 1 Diagram, 4 Charts |
| Abstrakt: |
Activation of β-adrenoreceptors in rat parotid acinar cells leads to copious exocrine protein secretion. Additionally, β-adrenergic stimulation dramatically increases specific secretary protein synthesis and enhances N-linked glycosylation of secretary glycoproteins. Recently, efforts have been directed toward understanding the mechanisms underlying these biosynthetic events. We have been particularly interested in the receptor-mediated regulation of glycosylation. In this report, we evaluate available mechanistic information from the rat parotid gland and present initial data examining the ability of various regulatory agents to modulate N-linked glycosylation in enzymatically-dispersed cell aggregates from surgical specimens of human parotid glands. We conclude that glycosylation of human parotid N-linked glycoproteins may be regulated by extracellular signaling similar to that operative in the rat parotid gland. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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