| Autor: |
Lançoni, Glalcyara, Ravinal, Roberto Cuan, Costa, Roberto Silva, Roselino, Ana Maria |
| Předmět: |
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| Zdroj: |
International Journal of Dermatology; Jun2008, Vol. 47 Issue 6, p575-581, 7p, 4 Color Photographs, 1 Chart, 4 Graphs |
| Abstrakt: |
Background Porphyria cutanea tarda (PCT) is a metabolic disease characterized by vesicles and blisters in sun-exposed areas and scleroderma-like lesions in sun-exposed and non-sun-exposed areas. Mast cells participate in the pathogenesis of bullous diseases and diseases that show sclerosis, including PCT. Moreover, transforming growth factor-β (TGF-β) is the main cytokine in the development of tissue sclerosis. The correlation of mast cells and TGF-β with the lesions of PCT has not been examined, however. The possible role of mast cells and TGF-β (and the relationship between them) in the development of PCT lesions is discussed. Methods To quantify mast cells and cells expressing TGF-β in skin samples from patients with PCT and controls, immunohistochemical studies were performed in tissue sections allied to morphometric analyses. Results The numbers of mast cells and cells expressing TGF-β per square millimiter were increased in the PCT group relative to controls, and there was a direct and significant correlation between the mast cell number and cells expressing TGF-β in PCT. Conclusions The results suggest that the increased number of mast cells and of cells expressing TGF-β, as well as their direct correlation, may contribute to the pathogenesis of the skin lesions in PCT. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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