| Autor: |
Lin, G., R. F. Rea, Hammill, S. C., Hayes, D. L., Brady, P. A. |
| Předmět: |
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| Zdroj: |
Heart; Feb2008, Vol. 94 Issue 2, p186-190, 5p, 3 Charts, 5 Maps |
| Abstrakt: |
Background: Cardiac resynchronisation therapy (CAT) improves outcomes in selected patients with heart failure and left ventricular dysfunction. One mechanism of benefit is believed to be favourable ventricular remodelling. Whether CAT also decreases the frequency of ventricular arrhythmias and risk of sudden death is unknown. Objective: To determine the effect of CAT on frequency of ventricular arrhythmias and appropriate lCD therapies. Design: Aetrospective cohort study. Setting: Single-centre, tertiary care facility (Mayo Clinic). Patients: 52 patients (46 male), aged 70 (SD 10) years, who underwent upgrade from an implantable cardioverter defibrillator (ICD) to a CAT-defibrillator were included. Interventions: Upgrade of lCD to CRT-defibrillator. Main Outcome Measures: Frequency of ventricular arrhythmias prior to and following upgrade to CAT device. Results: Ejection fraction increased from 22% (SD 8%) to 27% (SD 11%) following CAT. However, the frequency of non-sustained ventricular arrhythmias, sustained ventricular arrhythmias, and ventricular fibrillation was not significantly changed prior to and following CAT (2.38 (SD 9.78) vs 58.51 (SD 412.73) per patient per month, p = 0.66; 0.07 (SD 0.17) vs 0.16 (SD 0.52), p = 0.70; 0.05 (SD 0.12) vs 0.25 (SD 1.40), p = 0.12). Conclusions: CAT is not associated with a decrease in the frequency of ventricular arrhythmia or appropriate device therapy. Thus, use of CAT alone is not beneficial in decreasing the frequency of ventricular arrhythmias or the risk of appropriate ICD therapies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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