| Autor: |
Sheng Wei, Jun-min Zhou, Xinghong Chen, Shah, Radhika N., Liu, Jinhong, Orcutt, Timothy M., Traver, David, Djeu, Julie Y., Litman, Gary W., Yoder, Jeffrey A. |
| Předmět: |
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| Zdroj: |
Immunogenetics; Oct2007, Vol. 59 Issue 10, p813-821, 9p, 1 Black and White Photograph, 3 Diagrams, 2 Charts |
| Abstrakt: |
Both inhibitory and activating forms of natural killer (NK) cell receptors are found in mammals. The activating receptors play a direct role in the recognition of virally infected or transformed cells and transduce activating signals into the cell by partnering with an adaptor protein, which contains a cytoplasmic activation motif. Activating NK receptors encoded by the mammalian leukocyte receptor complex (e.g., killer cell immunoglobulin-like receptors) and the natural killer complex (e.g., Ly49s) partner with the adaptor protein DAP12, whereas NK receptors encoded in the CD94/NKG2 complex partner with the adaptor protein DAP10. Novel immune-type receptors (NITRs) found in bony fish share several common features with immunoglobulin-type NK receptors. Nitr9 is a putative activating receptor in zebrafish that induces cytotoxicity within the context of human NK cells. One isoform of Nitr9, Nitr9L, is shown here to preferentially partner with a zebrafish ortholog of Dap12. Cross-linking the Nitr9L–Dap12 complex results in activation of the phosphytidylinositol 3-kinase→AKT→extracellular signal-regulated kinase pathway suggesting that the DAP12-based activating pathway is conserved between bony fish and mammals. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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