| Autor: |
Dawiskiba, Tomasz, Pupka, Artur, Skóra, Jan, Janczak, Dariusz, Pawłowski, Stanisław, Krawczyk, Zbigniew, Szyber, Przemysław P., Szyber, Piotr |
| Předmět: |
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| Zdroj: |
Polish Surgery / Chirurgia Polska; 2007, Vol. 9 Issue 1, p25-33, 9p |
| Abstrakt: |
Background: The aim of the study was to evaluate the effect of Allopurinol on intestinal ischemia-reperfusion injury and xanthine oxidase system. Material and methods: 70 Buffalo rats were divided into 5 groups of 14. Group I was the control group. The animals of groups II and IV were subjected to 50 minutes of acute intestinal ischemia. The animals of groups III and V were subjected to 50 minutes of acute intestinal ischemia followed by 60 minutes of reperfusion. The rats of group IV and V were pretreated with Allopurinol for three days before surgery. Total intestinal ischemia was produced by clamping the mesenteric vessels. Mucosal changes underwent histopathological evaluation according to the scoring system (0-5) described by Chiu. Biochemical tests of xanthine oxidase activity were performed in supernatants of small intestine homogenates. Results: The administration of Allopurinol significantly reduced mesenteric ischemia-reperfusion injury as weft as intestinal xanthine exidase activity. However, there was no significant difference in the xanthine oxidase activity between non-pretreated rats subjected to ischemic processes and the control group. It was also noted that beneficial action of Allopurinol began during the ischemic phase, before reperfusion. Conclusions: It can be concluded that the protective effect of Allopurinol against intestinal ischemia-reperfusion is not only related to the reperfusion component, The role of xanthine oxidase in the processes of injury resulting from blood flow disturbances remains a matter of controversy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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