Live time-lapse imaging of migrating neural crest cells reveals novel mechanisms that mediate the formation and differentiation of cells in the avian peripheral nervous system.

Autor:	Lefcort, Frances, George, Lynn, Kasemeier, Jennifer, Kulesa, Paul M.
Předmět:	CELL differentiation CELLS NEURAL crest PERIPHERAL nervous system NERVOUS system
Zdroj:	FASEB Journal; Apr2007, Vol. 21 Issue 5, pA80-A80, 1/6p
Abstrakt:	One of the most intriguing cell populations in the developing embryo is the neural crest which undergo an epithelial-to-mesenchymal transformation as they delaminate from the neural tube and migrate along stereotyped trajectories throughout the embryo. In the cranial region they contribute to the cranial ganglia, and much of the mesectoderm of the face. In the trunk, their derivatives include the dorsal root ganglia (DRG) and sympathetic ganglia (SG). Our lab has been interested in the cellular and molecular interactions that regulate the behavior of neural crest cells as they migrate through the trunk to form the DRG and SG. We have been imaging migrating neural crest cells in an explant system we developed, in combination with in ovo electroporation of various gain-and loss-of function constructs in order to identify the mechanisms mediating the differentiation of different cell types within the DRG and the cues that sculpt the emergence of the chain of primary and secondary SG. The data I will present identifies mechanisms mediating segregation of neural crest cells into discrete SG and evidence for a novel, prespecified population of neural crest cells that gives rise to a specific subset of cells within the DRG. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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