| Autor: |
HAHN, BEVRA H., EBLING, FANNY, SINGH, RAM R., SINGH, RAM P., KARPOUZAS, GEORGE, CAVA, ANTONIO |
| Předmět: |
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| Zdroj: |
Annals of the New York Academy of Sciences; 2005, Vol. 1051 Issue 1, p433-441, 9p |
| Abstrakt: |
The hyperactive interaction between helper T cells and autoimmune B cells in individuals predisposed to systemic lupus erythematosus (SLE) can be interrupted by induction of regulatory and suppressor T cells. Using two strategies—high dose tolerance to an immunoglobulin-derived peptide, and minigene vaccination with DNA encoding T cell epitopes presented by MHC class I molecules—our group has induced at least three types of regulatory/suppressive T cells. They include CD8+ T cells that suppress helper T cells by cytokine secretion, CD8+ T suppressors that kill B cells making anti-DNA antibodies, and peptide-binding CD4+CD25+ regulatory T cells that suppress B cells by direct cell contact. Each of these lymphocyte subsets suppresses anti- DNA antibody production and delays the onset of nephritis in BWF1 lupusprone mice. Patients with SLE have amino acid sequences similar to those from murine anti-DNA antibodies used in these studies, and at similar locations in the VH regions of anti-DNA immunoglobulins. Therefore, strategies described here might ultimately be useful in therapy of the human disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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