| Autor: |
Mönnikes, Hubert, Pfaffenberger, Bernd, Gatz, Gudrun, Hein, Jasper, Bardhan, Karna Dev |
| Předmět: |
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| Zdroj: |
Digestion; 2007 Supplement 1, Vol. 75, p62-68, 7p, 1 Diagram, 3 Charts |
| Abstrakt: |
Background/Aims: A prime concern for gastroesophageal reflux disease (GERD) patients is fast symptom control. Sparse valid information is available on the rapidity of the effect of proton pump inhibitors in providing symptom relief. The new reflux questionnaire ReQuestTM is validated for daily assessment of changes in GERD symptoms. Therefore, this study investigated the efficacy of 20 mg pantoprazole and 20 mg esomeprazole with regard to the time to symptom relief in patients with endoscopy-negative GERD (enGERD) using ReQuestTM. Methods: 529 patients were treated with pantoprazole or esomeprazole over 4 weeks. ReQuestTM symptom scores were assessed daily. The mean and median times to first and sustained symptom relief were determined. Results: Median time to first symptom relief was 2 days for both drugs (intention-to-treat population). The median time to sustained symptom relief was 3 days shorter with pantoprazole (10.0 vs. 13.0 days). The Hodges-Lehmann estimator for the difference in time to reach first and sustained symptom relief between both groups was 0.00 days. For both variables the one-sided 95% CI (Moses) was [0.00; ∞[, documenting no significant differences between the treatment groups. Conclusions: The rapidity of symptom control can be evaluated by clinically significant parameters using ReQuestTM. Pantoprazole and esomeprazole are equally effective in the time to first and sustained symptom relief. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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