| Autor: |
Yamada, Yoichi, Shirakawa, Tomoyo, Taylor, Todd D., Okamura, Kohji, Soejima, Hidenobu, Uchiyama, Michiko, Iwasaka, Tsuyoshi, Mukai, Tsunehiro, Muramoto, Ken-Ichiro, Sakaki, Yoshiyuki, Ito, Takashi |
| Předmět: |
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| Zdroj: |
DNA Sequence; Aug2006, Vol. 17 Issue 4, p300-306, 7p, 2 Diagrams, 1 Chart, 1 Graph |
| Abstrakt: |
It was generally believed that autosomal CpG islands (CGIs) escape methylation. However, our comprehensive analysis of allelic methylation status of 149 CGIs on human chromosome 21q revealed that a sizable fraction of them are methylated on both alleles even in normal blood cells. Here, we performed a similar analysis of 656 CGIs on chromosome 11q, which is gene-rich in contrast with 21q. The results indicate that 11q contains less methylated CGIs, especially those with tandem repeats and those in the coding or 3'-untranslated regions (UTRs), than 21q. Thus, methylation status of CGIs may substantially differ from one chromosome to another. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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