| Autor: |
GOURDIE, ROBERT G., GHATNEKAR, GAUTAM S., O'QUINN, MICHAEL, RHETT, MATTHEW J., BARKER, RALPH J., ZHU, CHING, JOURDAN, JANE, HUNTER, ANDREW W. |
| Předmět: |
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| Zdroj: |
Annals of the New York Academy of Sciences; 2006, Vol. 1080 Issue 1, p49-62, 14p, 4 Black and White Photographs |
| Abstrakt: |
Intercellular connectivity mediated by gap junctions (GJs) composed of connexin43 (C×43) is critical to the function of excitable tissues such as the heart and brain. Disruptions to C×43 GJ organization are thought to be a factor in cardiac arrhythmias and are also implicated in epilepsy. This article is based on a presentation to the 4th Larry and Horti Fairberg Workshop on Interactive and Integrative Cardiology and summarizes the work of Gourdie and his lab on C×43 GJs in the heart. Background and perspective of recently published studies on the function of C×43-interacting protein zonula occludens-(ZO)-1 in determining the organization of GJ plaques are provided. In addition how a peptide containing a PDZ-binding sequence of C×43, developed as part of the work on cardiac GJ organization is also described, which has led to evidence for novel and unexpected roles for C×43 in modulating healing following tissue injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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