Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.

Autor: Kennedy, L. J., Quarmby, S., Happ, G. M., Barnes, A., Ramsey, I. K., Dixon, R. M., Catchpole, B., Rusbridge, C., Graham, P. A., Hillbertz, N. S., Roethel, C., Dodds, W. J., Carmichael, N. G., Ollier, W. E. R.
Předmět:
Zdroj: Tissue Antigens; Jul2006, Vol. 68 Issue 1, p82-86, 5p, 4 Charts
Abstrakt: Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index